Potensi multi-target, mekanisme dan bukti klinis Zea mays L. untuk kesehatan: Tinjauan naratif: The multi-target potential, mechanisms, and clinical evidence of Zea mays L. for health: A narrative review

I Made Dwi Mertha Adnyana; Muhammad Rizky Pratama; Alreva Muhazier Jayaputra; Ni Luh Gede Sudaryati; Maykon Jhuly Martins de Paiva; Elsa Mega Suryani

doi:10.32795/bm04nz54

Authors

I Made Dwi Mertha Adnyana Departemen Mikrobiologi dan Parasitologi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Jambi https://orcid.org/0000-0002-7167-7612
Muhammad Rizky Pratama Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Jambi https://orcid.org/0009-0004-0859-9158
Alreva Muhazier Jayaputra Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Jambi https://orcid.org/0009-0006-3775-1571
Ni Luh Gede Sudaryati Departemen Biologi, Fakultas Kesehatan dan Sains, Universitas Hindu Indonesia https://orcid.org/0000-0003-3716-5215
Maykon Jhuly Martins de Paiva Natural Products Laboratory, Department of Pharmacy, Health Sciences School, University of Brasília (UnB), Brazil; School of Medicine, University of Gurupi (UnirG), Brazil https://orcid.org/0000-0002-6228-4550
Elsa Mega Suryani Departemen Mikrobiologi, Fakultas Ilmu Kesehatan, Universitas Maarif Hasyim Latif https://orcid.org/0009-0000-5163-0457

DOI:

https://doi.org/10.32795/bm04nz54

Keywords:

Zea mays, Senyawa fitokimia, Antosianin, Mikrobioma saluran pencernaan, Pengobatan herbal

Abstract

Latar Belakang: Zea mays L. menjadi salah satu tanaman pangan utama dunia. Bagian rambut, tongkol, kelobot, biji berwarna dan dedaknya mengandung beragam senyawa bioaktif dengan potensi manfaat kesehatan, namun kompilasi bukti ilmiahnya masih terbatas. Tujuan: Menganalisis potensi fitokimia, mekanisme dan implikasi kesehatan dari bagian tanaman Zea mays L. Metode: Penelusuran dilakukan pada basis data PubMed/MEDLINE menggunakan kombinasi istilah terkait “Zea mays”, “corn silk”, “purple corn”, “anthocyanin”, dan “corn bran arabinoxylan”, dibatasi pada artikel open access dan tergolong artikel penelitian, brief report, short communication atau tinjauan serta diterbitkan pada rentang tahun 2015 hingga 2026. Seluruh data dianalisis secara deskriptif. Hasil: Dua belas artikel memenuhi kriteria dan diekstraksi. Temuan menunjukkan rambut jagung menunjukkan efek antihipertensi, antioksidan dan fotoprotektif melalui modulasi jalur NF-κB, Nrf2 dan mikrobiota usus pada model in vivo. Kandunga Antosianin jagung ungu berasosiasi dengan efek antiinflamasi, antiproliferatif pada hiperplasia prostat jinak dan perbaikan kognitif pada uji klinis perempuan menopause. Arabinoxylan dedak jagung memodulasi mikrobiota usus dan penanda metabolik pada uji klinis acak terkontrol manusia. Kesimpulan: Zea mays L. menyimpan potensi multi-target untuk kesehatan kardiovaskular, metabolik, dan kognitif, namun translasi klinis masih terbatas pada komponen arabinoxylan dan antosianin, sehingga standardisasi dan karakterisasi senyawa bagian tanaman, uji kandidat obat serta uji klinis masih diperlukan untuk menguatkan bukti terapeutiknya

Author Biographies

I Made Dwi Mertha Adnyana , Departemen Mikrobiologi dan Parasitologi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Jambi

Departemen Mikrobiologi dan Parasitologi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Jambi; Perhimpunan Ahli Epidemiologi Indonesia; Royal Society of Tropical Medicine and Hygiene, London, United Kingdom
Muhammad Rizky Pratama, Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Jambi

Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Jambi
Alreva Muhazier Jayaputra, Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Jambi

Program Studi Kedokteran, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Jambi
Ni Luh Gede Sudaryati, Departemen Biologi, Fakultas Kesehatan dan Sains, Universitas Hindu Indonesia

Departemen Biologi, Fakultas Kesehatan dan Sains, Universitas Hindu Indonesia
Maykon Jhuly Martins de Paiva, Natural Products Laboratory, Department of Pharmacy, Health Sciences School, University of Brasília (UnB), Brazil; School of Medicine, University of Gurupi (UnirG), Brazil

Natural Products Laboratory, Department of Pharmacy, Health Sciences School, University of Brasília (UnB), Brazil; School of Medicine, University of Gurupi (UnirG), Brazil
Elsa Mega Suryani, Departemen Mikrobiologi, Fakultas Ilmu Kesehatan, Universitas Maarif Hasyim Latif

Departemen Mikrobiologi, Fakultas Ilmu Kesehatan, Universitas Maarif Hasyim Latif

References

Bulut, N., Cantu-Jungles, T. M., Zhang, X., Mutlu, Z., Cakmak, M., & Hamaker, B. R. (2023). Matrix-entrapped fibers create ecological niches for gut bacterial growth. Scientific Reports, 13(1), 1884. https://doi.org/10.1038/s41598-023-27907-7

Colombo, R., Ferron, L., & Papetti, A. (2021). Colored corn: An up-date on metabolites extraction, health implication, and potential use. Molecules, 26(1), 199. https://doi.org/10.3390/molecules26010199

Deehan, E. C., Zhang, Z., Nguyen, N. K., Perez-Muñoz, M. E., Cole, J., Riva, A., Berry, D., Prado, C. M., & Walter, J. (2024). Adaptation to tolerate high doses of arabinoxylan is associated with fecal levels of Bifidobacterium. Gut Microbes, 16(1), 2363021. https://doi.org/10.1080/19490976.2024.2363021

Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J., Li, F., Hausmann, B., Spittler, A., Nazare, J.-A., Delzenne, N. M., Curtis, J. M., Wismer, W. V., Proctor, S. D., Bakal, J. A., … Walter, J. (2022). Elucidating the role of the gut microbiota in the physiological effects of dietary fiber. Microbiome, 10(1), 77. https://doi.org/10.1186/s40168-022-01248-5

Deepa, P., Hong, M., Sowndhararajan, K., & Kim, S. (2023). A review of the role of an anthocyanin, cyanidin-3-β-D-glucoside in obesity-related complications. Plants, 12(22), 3889. https://doi.org/10.3390/plants12223889

Ifie, S. E., Dangana, R. S., Swase, D., Ben Okon, M., Makena, W., Agunloye, M. O., Ugwu, C. N., Ifie, J. E., Odoma, S., Babangida, A. I., & Aja, P. M. (2026). Nutritional composition of Zea mays L: A comprehensive Review of Macronutrients, Micronutrients, and Bioactive Compounds. Open research Africa, 8, 15. https://doi.org/10.12688/openresafrica.16056.2

Kim, S.-O., Choi, A., Lee, H.-H., Lee, J.-Y., Park, S. J., & Kim, B.-H. (2025). Purple corn extract improves benign prostatic hyperplasia by inhibiting 5 alpha-reductase type 2 and inflammation in testosterone propionate-induced rats. Frontiers in Pharmacology, 15, 1485072. https://doi.org/10.3389/fphar.2024.1485072

Kim, Y.-H., Cho, A., Kwon, S.-A., Kim, M., Song, M., Han, H. W., Shin, E.-J., Park, E., & Lee, S.-M. (2019). Potential photoprotective effect of dietary corn silk extract on ultraviolet B-induced skin damage. Molecules, 24(14), 2587. https://doi.org/10.3390/molecules24142587

Li, Z., Zhang, H., He, L., Hou, Y., Che, Y., Liu, T., Xiong, S., Zhang, X., Luo, S., Liu, C., & Chen, T. (2023). Influence of structural features and feruloylation on fermentability and ability to modulate gut microbiota of arabinoxylan in in vitro fermentation. Frontiers in Microbiology, 13, 1113601. https://doi.org/10.3389/fmicb.2022.1113601

Ratha, J., Yongram, C., Panyatip, P., Powijitkul, P., Siriparu, P., Datham, S., Priprem, A., Srisongkram, T., & Puthongking, P. (2023). Polyphenol and tryptophan contents of purple corn (Zea mays L.) variety KND and butterfly pea (Clitoria ternatea) aqueous extracts: Insights into phytochemical profiles with antioxidant activities and PCA analysis. Plants, 12(3), 603. https://doi.org/10.3390/plants12030603

Wang, Y., Mao, J., Zhang, M., Liu, L., Zhu, Y., Gu, M., Zhang, J., Bu, H., Sun, Y., Sun, J., Ma, Y., Guo, L., Zheng, Y., & Liu, Q. (2024). An umbrella insight into the phytochemistry features and biological activities of corn silk: A narrative review. Molecules, 29(4), 891. https://doi.org/10.3390/molecules29040891

Wattanathorn, J., Kirisattayakul, W., & Somboonporn, W. (2025). A randomized controlled trial on the safety and cognitive benefits of a novel functional drink from a purple waxy corn byproduct in peri- and postmenopausal women. Antioxidants, 14(10), 1262. https://doi.org/10.3390/antiox14101262

Yao, G., Zhang, T., Qin, Z., Wang, Y., Gu, J., He, C., & Jin, J. (2026). Corn silk extract as a prebiotic exerts antihypertensive effects via gut microbiota modulation in hypertensive rats. Microbiology Spectrum, 14(3), e0144225. https://doi.org/10.1128/spectrum.01442-25